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KMID : 0613820090190020213
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Journal of Life Science
2009 Volume.19 No. 2 p.213 ~ p.218
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Effects of Relative Swimming Exercise Intensity on mRNA Expression of UCP-1, UCP-3 Brown Adipose Tissue and Blood Insulin, and Glucose in Rat
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Yoon Jin-Hwan
Oh Myung-Jin
Seo Tae-Bum
Kim Jong-Oh
Jang Moon-Nyeo
Park Seong-Tae
Kim Young-Pyo
Yoo Jae-Hyun
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Abstract
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The purpose of this study was to investigate the UCP-1, UCP-3 mRNA expression in brown adipose tissue with glycometabolism according to intensity and duration of swimming in rat. F344 rat were randomly divided into three groups (n=10 in each group): control (CON), low-intensity swimming (LIS) groups, and high-intensity swimming (HIS) groups. Animals in the LIS group were forced to swim in swimming pool for 30min once a day for 8 consecutive weeks with a light intensity. In the HIS group, the rats repeated fifteen 20-s swimming bouts with a weight equivalent to 10% of body weight for 8weeks, respectively. The present result demonstrated that in LIS group, serum insulin and glucose levels significantly decreased in LIS group compared to CON. Brown adipose tissue UCP-1 and UCP-3mRNA expression was significantly increase in LIS group compared to CON and HIS groups. From those results, it can be suggested that low-intensity swimming may improve glycometablism control by up-regulating UCP-1 and UCP-3mRNA expression.
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KEYWORD
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Swimming exercise, F344 rat, UCP mRNA, adipose tissue, blood insulin
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